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Diabetes in patients with idiopathic Parkinson's disease

Becker, C. and Brobert, G. P. and Johansson, S. and Jick, S. S. and Meier, C. R.. (2008) Diabetes in patients with idiopathic Parkinson's disease. Diabetes care, Vol. 31. pp. 1808-1812.

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Official URL: http://edoc.unibas.ch/dok/A6005531

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Abstract

OBJECTIVE: Previous observational studies reported inconsistent results on the association between diabetes and Parkinson's disease, and data on the risk of developing incident diabetes in relation to Parkinson's disease are scarce. We aimed at comparing the diabetes prevalence between patients with or without Parkinson's disease and at exploring the risk of developing incident diabetes associated with Parkinson's disease. RESEARCH DESIGN AND METHODS: We used the U.K.-based General Practice Research Database (GPRD) to 1) compare the diabetes prevalence between Parkinson's disease cases and a matched comparison group free of Parkinson's disease between 1994 and 2005 and to 2) conduct a follow-up study with a nested case-control analysis to quantify the risk of developing new-onset diabetes in association with Parkinson's disease. RESULTS: The diabetes prevalence was similar in patients with and without Parkinson's disease (adjusted odds ratio [OR] 0.95 [95% CI 0.80-1.14]). In the cohort analysis (incidence rate ratio [IRR] 0.55 [95% CI 0.38-0.81]) and in the nested case-control analysis (adjusted OR 0.53 [95% CI 0.33-0.87]), the risk of developing diabetes was lower in patients with Parkinson's disease than in subjects without. The adjusted OR for patients with Parkinson's disease who were current levodopa users of five or more prescriptions was 0.22 (0.10-0.48) and was 1.11 (0.50-2.45) for Parkinson's disease patients not using levodopa. CONCLUSIONS: In this observational study, diabetes prevalence was closely similar between patients with Parkinson's disease and subjects without. The risk of developing incident diabetes was lower for patients with Parkinson's disease than for patients without, a finding that was limited to Parkinson's disease patients who were using levodopa.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
UniBasel Contributors:Meier, Christoph R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Diabetes Association
ISSN:0149-5992
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:19

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