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Processing-dependent and -independent pathways for recognition of iodinated contrast media by specific human T cells

Keller, M. and Lerch, M. and Britschgi, M. and Tâche, V. and Gerber, B. O. and Lüthi, M. and Lochmatter, P. and Kanny, G. and Bircher, A. J. and Christiansen, C. and Pichler, W. J.. (2010) Processing-dependent and -independent pathways for recognition of iodinated contrast media by specific human T cells. Clinical & experimental allergy, Vol. 40. pp. 257-268.

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Official URL: http://edoc.unibas.ch/dok/A6005135

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Abstract

One to three percent of patients exposed to intravenously injected iodinated contrast media (CM) develop delayed hypersensitivity reactions. Positive patch test reactions, immunohistological findings, and CM-specific proliferation of T cells in vitro suggest a pathogenetic role for T cells. We have previously demonstrated that CM-specific T cell clones (TCCs) show a broad range of cross-reactivity to different CM. However, the mechanism of specific CM recognition by T cell receptors (TCRs) has not been analysed so far.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Bircher)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Bircher)
UniBasel Contributors:Bircher, Andreas J.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:0954-7894
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:19

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