Cutting edge : a naturally occurring mutation in CD1e impairs lipid antigen presentation

Tourne, S. and Maitre, B. and Collmann, A. and Layre, E. and Mariotti, S. and Signorino-Gelo, F. and Loch, C. and Salamero, J. and Gilleron, M. and Angénieux, C. and Cazenave, J. P. and Mori, L. and Hanau, D. and Puzo, G. and De Libero, G. and de la Salle, H.. (2008) Cutting edge : a naturally occurring mutation in CD1e impairs lipid antigen presentation. Journal of immunology, Vol. 180, H. 6. pp. 3642-3646.

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Official URL: http://edoc.unibas.ch/dok/A6006096

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The human CD1a-d proteins are plasma membrane molecules involved in the presentation of lipid Ags to T cells. In contrast, CD1e is an intracellular protein present in a soluble form in late endosomes or lysosomes and is essential for the processing of complex glycolipid Ags such as hexamannosylated phosphatidyl-myo-inositol, PIM(6). CD1e is formed by the association of beta(2)-microglobulin with an alpha-chain encoded by a polymorphic gene. We report here that one variant of CD1e with a proline at position 194, encoded by allele 4, does not assist PIM(6) presentation to CD1b-restricted specific T cells. The immunological incompetence of this CD1e variant is mainly due to inefficient assembly and poor transport of this molecule to late endosomal compartments. Although the allele 4 of CD1E is not frequent in the population, our findings suggest that homozygous individuals might display an altered immune response to complex glycolipid Ags.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Immunology (De Libero)
UniBasel Contributors:De Libero, Gennaro
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Assoc. of Immunologists
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:18

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