Flow loading induces oscillatory trajectories in a bloodstream parasite

Uppaluri, Sravanti and Heddergott, Niko and Stellamanns, Eric and Herminghaus, Stephan and Zöttl, Andreas and Stark, Holger and Engstler, Markus and Pfohl, Thomas. (2012) Flow loading induces oscillatory trajectories in a bloodstream parasite. Biophysical journal, Vol. 103, H. 6. pp. 1162-1169.

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Official URL: http://edoc.unibas.ch/dok/A6031553

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The dynamics of isolated microswimmers are studied in bounded flow using the African trypanosome, a unicellular parasite, as the model organism. With the help of a microfluidics platform, cells are subjected to flow and found to follow an oscillatory path that is well fit by a sine wave. The frequency and amplitudes of the oscillatory trajectories are dependent on the flow velocity and cell orientation. When traveling in such a manner, trypanosomes orient upstream while downstream-facing cells tumble within the same streamline. A comparison with immotile trypanosomes demonstrates that self-propulsion is essential to the trajectories of trypanosomes even at flow velocities up to ?40 times higher than their own swimming speed. These studies reveal important swimming dynamics that may be generally pertinent to the transport of microswimmers in flow and may be relevant to microbial pathogenesis.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Biophysikalische Chemie (Pfohl)
UniBasel Contributors:Pfohl, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Biophysical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:23
Deposited On:08 Nov 2012 16:17

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