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Automated Protein Structure Modeling with SWISS-MODEL Workspace and the Protein Model Portal

Bordoli, Lorenza and Schwede, Torsten. (2012) Automated Protein Structure Modeling with SWISS-MODEL Workspace and the Protein Model Portal. In: Homology Modeling: Methods and Protocols, Vol. 857. New York, USA, pp. 107-136.

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Official URL: http://edoc.unibas.ch/dok/A6002652

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Abstract

Comparative protein structure modeling is a computational approach to build three-dimensional structural models for proteins using experimental structures of related protein family members as templates. Regular blind assessments of modeling accuracy have demonstrated that comparative protein structure modeling is currently the most reliable technique to model protein structures. Homology models are often sufficiently accurate to substitute for experimental structures in a wide variety of applications. Since the usefulness of a model for specific application is determined by its accuracy, model quality estimation is an essential component of protein structure prediction. Comparative protein modeling has become a routine approach in many areas of life science research since fully automated modeling systems allow also nonexperts to build reliable models. In this chapter, we describe practical approaches for automated protein structure modeling with SWISS-MODEL Workspace and the Protein Model Portal.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede)
UniBasel Contributors:Schwede, Torsten
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Publisher:Humana Press
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:14

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