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Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study

Wolbers, M. and Bucher, H. C. and Furrer, H. and Rickenbach, M. and Cavassini, M. and Weber, R. and Schmid, P. and Bernasconi, E. and Hirschel, B. and Battegay, M. and Swiss, HIV Cohort Study. (2008) Delayed diagnosis of HIV infection and late initiation of antiretroviral therapy in the Swiss HIV Cohort Study. HIV medicine, Vol. 9. pp. 397-405.

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Official URL: http://edoc.unibas.ch/dok/A6006616

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Abstract

OBJECTIVES: To investigate delayed HIV diagnosis and late initiation of antiretroviral therapy (ART) in the Swiss HIV Cohort Study. METHODS: Two sub-populations were included: 1915 patients with HIV diagnosis from 1998 to 2007 and within 3 months of cohort registration (group A), and 1730 treatment-naïve patients with CD4<or=200 cells/microL before their second cohort visit (group B). In group A, predictors for low initial CD4 cell counts were examined with a median regression. In group B, we studied predictors for CD4or=200 cells/microL; 18% and 2% dropped to CD4 >200 and >50 cells/microL without ART, respectively. Sub-Saharan origin was associated with lower probability of CD4 >200 cells/microL without ART during follow-up. Median CD4 count at ART initiation was 207 and 253 cells/microL in groups A and B, respectively. CONCLUSIONS: CD4>200 cells/microL and, particularly, CD4>50 cells/microL before starting ART are predominantly caused by late presentation. Earlier HIV diagnosis is paramount.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Battegay, Manuel E.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:1464-2662
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:14

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