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Urinary C4d does not correlate with C4d-staining in peritubular capillaries but reflects nonspecific glomerular injury

Hönger, G. and Mayr, M. and Dickenmann, M. and Mihatsch, M. J. and Schaub, S.. (2008) Urinary C4d does not correlate with C4d-staining in peritubular capillaries but reflects nonspecific glomerular injury. Transplantation, Vol. 85. pp. 542-546.

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Official URL: http://edoc.unibas.ch/dok/A6005493

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Abstract

BACKGROUND: C4d-staining in peritubular capillaries (PTC) in allograft biopsies is a hallmark of antibody-mediated rejection (AMR). This study investigated whether urinary C4d correlates with C4d-staining in PTC, allowing for a noninvasive screening procedure. METHODS: Urine samples from 34 patients with diffuse C4d-staining in PTC (C4d-pos group) and 68 urine samples from patients with negative C4d-staining in PTC (C4d-negative group) matched 1:2 according to proteinuria and time posttransplant were compared regarding urinary C4d-levels. RESULTS: Overall, urinary C4d/creatinine-ratios (C4d/C) were not different between the C4d-positive and the C4d-negative group (P=0.55). Urinary C4d/C strongly correlated with total protein/creatinine-ratios (P/C) (r2=0.53; P50 mg/mmol (P=0.57) and P/C50 mg/mmol than in patients with P/C>50 mg/mmol (P>or=0.005). Furthermore, longitudinal analysis in 3 patients with distinct clinico-pathological courses demonstrated that urinary C4d/C closely followed P/C regardless of C4d-staining in PTC. CONCLUSION: Urinary C4d does not correlate with C4d-staining in PTC but reflects nonspecific glomerular injury. Therefore, urinary C4d is likely not a useful biomarker for non-invasive screening and monitoring of AMR.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Nephrologie > Transplantationsimmunologie und Nephrologie (Steiger)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Nephrologie > Transplantationsimmunologie und Nephrologie (Steiger)
UniBasel Contributors:Mihatsch, Michael J. and Dickenmann, Michael Jan and Schaub, Stefan
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:0041-1337
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:11

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