A comparison of the blood pressure changes of lumiracoxib with those of ibuprofen and naproxen

Farkouh, M. E. and Verheugt, F. W. and Ruland, S. and Kirshner, H. and Jeger, R. and Gitton, X. and Krammer, G. and Stricker, K. and Sallstig, P. and Mellein, B. and Matchaba, P. and Chesebro, J. H.. (2008) A comparison of the blood pressure changes of lumiracoxib with those of ibuprofen and naproxen. Journal of clinical hypertension, Vol. 10. pp. 592-602.

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Official URL: http://edoc.unibas.ch/dok/A6006608

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The 52-week Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET) investigated the gastrointestinal and cardiovascular safety profile of lumiracoxib 400 mg once daily compared with 2 traditional nonsteroidal anti-inflammatory drugs (NSAIDs): ibuprofen 800 mg 3 times daily and naproxen 500 mg twice daily. Data from TARGET were analyzed to examine the effect of lumiracoxib compared with ibuprofen and naproxen on blood pressure (BP), incidence of de novo and aggravated hypertension, prespecified edema events, and congestive heart failure. Lumiracoxib resulted in smaller changes in BP as early as week 4. Least-squares mean change from baseline at week 4 for systolic BP was +0.57 mm Hg with lumiracoxib compared with +3.14 mm Hg with ibuprofen (P>.0001) and +0.43 with lumiracoxib compared with +1.80 mm Hg with naproxen (P>.0001). In conclusion, the use of lumiracoxib and traditional NSAIDs results in differing BP changes; these might be of clinical relevance.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie
UniBasel Contributors:Jeger, Raban
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:11

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