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Hierarchical Organization of Purely Peptidic Amphiphiles into Peptide Beads

Ouboter, D. D. and Schuster, T. B. and Mantion, A. and Meier, W.. (2011) Hierarchical Organization of Purely Peptidic Amphiphiles into Peptide Beads. Journal of Physical Chemistry C, 115 (30). pp. 14583-14590.

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Official URL: http://edoc.unibas.ch/dok/A6001622

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Abstract

A broad range of new properties is emerging from supramolecular aggregates as they pass beyond the limitations of simple molecules. Self-assembled structures of purely peptidic amphiphiles may exploit such properties to produce biocompatible, smart materials for drug administration. In aqueous media, the solid-phase derived amphiphilic undecapeptide described herein (Ac-X(3)-gT) forms self-assembled particles of spherical shape with diameters between 200 and 1500 nm, termed "peptide beads". The beads result from hierarchical organization of micellar-like structures, a fact determined by a combination of investigations carried out by electron and atomic force microscopy (AFM), static and dynamic light scattering, and small-angle X-ray scattering. These highly ordered structures agree with the concept of multicompartmentization and represent the first example of supramicellar assemblies based purely on peptides. New structural insights, as presented here, allow a better understanding of the beads' capacity to embed hydrophobic and hydrophilic payloads and therefore provide new perspectives for drug delivery applications that may result from this new class of material.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:1932-7447
e-ISSN:1932-7455
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:04 Jun 2018 12:51
Deposited On:08 Nov 2012 16:10

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