edoc

Early age of menarche, lung function and adult asthma

Macsali, Ferenc and Real, Francisco Gómez and Plana, Estel and Sunyer, Jordi and Anto, Josep and Dratva, Julia and Janson, Christer and Jarvis, Deborah and Omenaas, Ernst Reidar and Zemp, Elisabeth and Wjst, Matthias and Leynaert, Benedicte and Svanes, Cecilie. (2011) Early age of menarche, lung function and adult asthma. American journal of respiratory and critical care medicine, Vol. 183, H. 1. pp. 8-14.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6002172

Downloads: Statistics Overview

Abstract

RATIONALE: Hormonal and metabolic status appears to influence lung health in women, and there are findings suggesting that early menarche may be related to asthma, cardiovascular disease, diabetes and breast cancer. OBJECTIVES: This study investigates whether age of menarche was related to adult lung function and asthma. MEASUREMENTS: Among participants in the European Community Respiratory Health Survey II, 3354 women aged 27-57 years from random population samples in 21 centers responded to a questionnaire concerning women's health (1998-2002). 2873 had lung function measurements, 2136 measurements of bronchial hyper reactivity (BHR) and 2743 IgE measurements. Logistic, linear and negative binomial regression analyses included adjustment for age, height, body mass index, education, smoking, family size and centre. MAIN RESULTS: Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were lower and asthma more common in women with early menarche. Women reporting menarche >/=10 years as compared with women with menarche at age 13 years (reference category) had lower FEV1 (adjusted difference -113ml, 95%CI -196 to -33) and FVC (-126ml [-223 to -28]); also lower FEV1 in percent of predicted (-3.28% [-6.25 to -0.30]) and FVC % predicted (-3.63% [-6.64 to -0.62]). Women with early menarche more often had asthma symptoms (OR 1.80, 95%CI 1.09-2.97), asthma with BHR (2.79[1.06-7.34]) and higher asthma symptom score (mean ratio 1.58, 95%CI 1.12-2.21). CONCLUSIONS: Women with early menarche had lower lung function and more asthma in adulthood. This supports a role for metabolic and hormonal factors in womenas respiratory health.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Gender and Health (Zemp Stutz)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin
UniBasel Contributors:Zemp Stutz, Elisabeth and Dratva, Julia
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Thoracic Society
ISSN:0003-0805
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:01 Mar 2013 11:08
Deposited On:08 Nov 2012 16:09

Repository Staff Only: item control page