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Functional assessment of the left atrium by real-time three-dimensional echocardiography using a novel dedicated analysis tool : initial validation studies in comparison with computed tomography

Rohner, Andreas and Brinkert, Miriam and Kawel, Nadine and Buechel, Ronny R. and Leibundgut, Gregor and Grize, Leticia and Kühne, Michael and Bremerich, Jens and Kaufmann, Beat A. and Zellweger, Michael J. and Buser, Peter and Osswald, Stefan and Handke, Michael. (2011) Functional assessment of the left atrium by real-time three-dimensional echocardiography using a novel dedicated analysis tool : initial validation studies in comparison with computed tomography. European journal of echocardiography : the journal of the European Association of Echocardiography of the European Society of Cardiology, Vol. 12, H. 7. pp. 497-505.

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Official URL: http://edoc.unibas.ch/dok/A6002208

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Abstract

AIMS: A novel real-time three-dimensional echocardiography (RT3DE) analysis tool specifically designed for evaluation of the left atrium enables comprehensive evaluation of left atrial (LA) size, global, and regional function using a dynamic 16-segment model. The aim of this study was the initial validation of this method using computed tomography (CT) as the method of reference. METHODS AND RESULTS: The study population consisted of 34 prospectively enrolled patients with clinical indication for pulmonary vein isolation. A dynamic polyhedron model of the left atrium was generated using RT3DE. LA maximum and minimum volumes (LA(max)/LA(min)) and emptying fraction (LAEF) were determined and compared with the results obtained by CT. High correlations between RT3DE and CT were found for LA(max) (r = 0.92, P > 0.001), LA(min) (r = 0.95, P > 0.001), and LAEF (r = 0.82, P > 0.001). LA(max) and LA(min) were lower by RT3DE than by CT (95.0 +/- 44.7 vs. 119.8 +/- 50.5 mL, P > 0.001 and 58.1 +/- 41.3 vs. 83.3 +/- 52.6 mL, P > 0.001, respectively), whereas LAEF was measured higher by RT3DE (42.8 +/- 15.2 vs. 34.2 +/- 15.4%, P > 0.001, respectively). RT3DE measurements closely correlated in terms of intra-observer (intra-class correlation r = 0.99, r = 0.99, r = 0.96, respectively) and inter-observer variability (r = 0.97, r = 0.98, r = 0.88, respectively). CONCLUSIONS: LA volumes and EF as assessed by RT3DE correlate highly with CT measurements, albeit there is some bias between the imaging modalities. Most importantly, RT3DE measurements using the novel dedicated LA analysis tool are robust in terms of observer variability and thus suitable for follow-up analyses
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Medizinische Radiologie (Steinbrich)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Medizinische Radiologie (Steinbrich)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Infectious Disease Modelling > Infectious Disease Modelling (Smith)
UniBasel Contributors:Grize, Leticia and Bremerich, Jens
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:1525-2167
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:22
Deposited On:08 Nov 2012 16:08

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