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Calf muscles at blood oxygen level-dependent MR imaging: aging effects at postocclusive reactive hyperemia

Schulte, A. C. and Aschwanden, M. and Bilecen, D.. (2008) Calf muscles at blood oxygen level-dependent MR imaging: aging effects at postocclusive reactive hyperemia. Radiology, Vol. 247. pp. 482-489.

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Official URL: http://edoc.unibas.ch/dok/A6002861

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Abstract

PURPOSE: To prospectively investigate age-related changes in muscle reperfusion by using blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging of the calf in young and elderly healthy volunteers during postocclusive reactive hyperemia. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained. Eleven healthy elderly (mean age, 64.0 years +/- 6.4 [standard deviation]; six men, five women) and 17 healthy young volunteers (mean age, 30.3 years +/- 6.5; seven men, 10 women) underwent muscle BOLD MR imaging of the calf. A fat-suppressed T2*-weighted single-shot multiecho echo-planar imaging sequence was used. Temporary vascular occlusion was induced with suprasystolic cuff compression of the thigh. T2* time courses of the muscle BOLD MR signal intensity were obtained from four calf muscles and were characterized by the following curve parameters: hyperemia peak value, time to peak, and T2* end value after 360 seconds of hyperemia. Differences in these parameters between the two cohorts were assessed by using a Student t test. RESULTS: Considerably lower T2* maxima were observed in the elderly group during hyperemia (P > .005), with a mean hyperemia peak value of 13.1% +/- 3.0 compared with 18.9% +/- 4.8 in young healthy adults. Peaking occurred earlier in the elderly group (P > .05), with a mean time to peak of 32.2 seconds +/- 10.6 compared with 43.1 seconds +/- 10.7 in young adults. Furthermore, the elderly group had a significantly slower decrease of the muscle BOLD signal after the hyperemia peak (P > .001), which led to a higher end value of 8.6% +/- 3.0 compared with 2.6% +/- 2.1 in the young group. CONCLUSION: BOLD MR imaging results of the calf demonstrated statistically significant age-dependent differences in the rate, intensity, and recovery of the postocclusive muscle BOLD signal.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB
UniBasel Contributors:Bilecen, Deniz
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:The Radiological Society of North America
ISSN:0033-8419
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:32
Deposited On:11 Oct 2012 15:30

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