Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition

Manson, S. C. and Wegner, C. and Filippi, M. and Barkhof, F. and Beckmann, C. and Ciccarelli, O. and De Stefano, N. and Enzinger, C. and Fazekas, F. and Agosta, F. and Gass, A. and Hirsch, J. and Johansen-Berg, H. and Kappos, L. and Korteweg, T. and Polman, C. and Mancini, L. and Manfredonia, F. and Marino, S. and Miller, D. H. and Montalban, X. and Palace, J. and Rocca, M. and Ropele, S. and Rovira, A. and Smith, S. and Thompson, A. and Thornton, J. and Yousry, T. and Frank, J. A. and Matthews, P. M.. (2008) Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition. Experimental brain research, Vol. 187. pp. 25-31.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6003926

Downloads: Statistics Overview


Motor control demands coordinated excitation and inhibition across distributed brain neuronal networks. Recent work has suggested that multiple sclerosis (MS) may be associated with impairments of neuronal inhibition as part of more general progressive impairments of connectivity. Here, we report results from a prospective, multi-centre fMRI study designed to characterise the changes in patients relative to healthy controls during a simple cued hand movement task. This study was conducted at eight European sites using 1.5 Tesla scanners. Brain deactivation during right hand movement was assessed in 56 right-handed patients with relapsing-remitting or secondary progressive MS without clinically evident hand impairment and in 60 age-matched, healthy subjects. The MS patients showed reduced task-associated deactivation relative to healthy controls in the pre- and postcentral gyri of the ipsilateral hemisphere in the region functionally specialised for hand movement control. We hypothesise that this impairment of deactivation is related to deficits of transcallosal connectivity and GABAergic neurotransmission occurring with the progression of pathology in the MS patients. This study has substantially extended previous observations with a well-powered, multicentre study. The clinical significance of these deactivation changes is still uncertain, but the functional anatomy of the affected region suggests that they could contribute to impairments of motor control.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Neuroimmunologie (Kappos)
UniBasel Contributors:Kappos, Ludwig
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:11 Oct 2012 15:32
Deposited On:11 Oct 2012 15:29

Repository Staff Only: item control page