Can polymeric vesicles that confine enzymatic reactions act as simplified organelles?

Tanner, Pascal and Egli, Stefan and Balasubramanian, Vimalkumar and Onaca, Ozana and Palivan, Cornelia and Meier, Wolfgang. (2011) Can polymeric vesicles that confine enzymatic reactions act as simplified organelles? FEBS Letters, 585 (11). pp. 1699-1706.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6001627

Downloads: Statistics Overview


In various pathological conditions an advantage may be gained by reinforcing an intrinsic organismal response. This can be achieved, for example, by enzyme replacement therapy, which can amplify specific, intrinsic activities of the organelles. In this respect, polymeric nanoreactors composed of vesicles that encapsulate an enzyme or a combination of enzymes in their cavities represent a novel approach in therapeutic applications because they behave like simplified organelles. As compartments, polymeric vesicles possess a membrane that is more stable than the corresponding lipid membrane of liposomes, with the dual role of protecting enzymes and simultaneously allowing them to act in situ. A complex scenario of requirements must be fulfilled by enzyme-containing polymeric nanoreactors if they are to function under biological conditions and serve to model organelles. Nanoreactors are described here in terms of the existing models and the challenges faced in developing artificial organelles for therapeutic applications. We will focus on describing how polymeric vesicles can be used to provide a protected compartment for enzymatic reactions, and serve as simplified organelles inside cells. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Makromolekulare Chemie (Meier)
UniBasel Contributors:Balasubramanian, Vimalkumar and Palivan, Cornelia G and Onaca, Ozana and Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Apr 2017 07:31
Deposited On:11 Oct 2012 15:25

Repository Staff Only: item control page