Compressibility of binary powder formulations : investigation and evaluation with compaction equations

Gentis, Nicolaos D. and Betz, Gabriele. (2012) Compressibility of binary powder formulations : investigation and evaluation with compaction equations. Journal of pharmaceutical sciences, Vol. 101, H. 2. pp. 777-793.

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Official URL: http://edoc.unibas.ch/dok/A6002077

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The purpose of this work was to investigate and evaluate the powder compressibility of binary mixtures containing a well-compressible compound (microcrystalline cellulose) and a brittle active drug (paracetamol and mefenamic acid) and its progression after a drug load increase. Drug concentration range was 0%-100% (m/m) with 10% intervals. The powder formulations were compacted to several relative densities with the Zwick material tester. The compaction force and tensile strength were fitted to several mathematical models that give representative factors for the powder compressibility. The factors k and C (Heckel and modified Heckel equation) showed mostly a nonlinear correlation with increasing drug load. The biggest drop in both factors occurred at far regions and drug load ranges. This outcome is crucial because in binary mixtures the drug load regions with higher changeover of plotted factors could be a hint for an existing percolation threshold. The susceptibility value (Leuenberger equation) showed varying values for each formulation without the expected trend of decrease for higher drug loads. The outcomes of this study showed the main challenges for good formulation design. Thus, we conclude that such mathematical plots are mandatory for a scientific evaluation and prediction of the powder compaction process. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:777-793, 2012.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Industrial Pharmacy Lab (Betz)
UniBasel Contributors:Betz, Gabriele
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:31
Deposited On:11 Oct 2012 15:19

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