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Parkinson's disease or Parkinson symptoms following seasonal influenza

Toovey, Stephen and Jick, Susan S. and Meier, Christoph R.. (2011) Parkinson's disease or Parkinson symptoms following seasonal influenza. Influenza and other respiratory viruses, Vol. 5, H. 5. pp. 328-333.

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Official URL: http://edoc.unibas.ch/dok/A6001552

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Abstract

Influenza may cause neurological sequelae and has been associated with encephalitis lethargica, an entity displaying Parkinson's disease (PD) signs and symptoms that followed the 1918 influenza pandemic. We studied the association between diagnosed influenza and idiopathic PD or Parkinson symptoms (PS) not followed by a firm PD diagnosis.; We used the UK-based General Practice Research Database to perform a case-control analysis. We identified cases who developed an incident diagnosis of PD or PS between 1994 and March 2007, and we matched four controls on age, gender, general practice, calendar time, and history in the database to each case. We calculated odds ratios (OR) with 95% confidence intervals (CI) using conditional logistic regression to assess the relative risk of developing PD or PS in association with previous influenza diagnoses.; We identified 3976 PD cases and 18 336 PS cases. The risk of developing PD was not associated with previous influenza infections. However, PS was associated with recent influenza (last infection 0-29 days: OR 3·03, 95% CI 1·94-4·74; 30-364 days: OR 1·36, 95% CI 1·14-1·63), number of influenza episodes (1 attack: OR 1·20, 95% CI 1·12-1·28; 2 attacks: OR 1·52, 95% CI 1·28-1·81; ?3 attacks: OR 2·00, 95% CI 1·45-2·75), and severity of preceding influenza infections (?1 severe attack: OR 1·45, 95% CI 1·25-1·68).; Influenza is associated with PD-like symptoms such as tremor, particularly in the month after an infection, but not with an increased risk of developing idiopathic PD.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Klinische Pharmazie/Spitalpharmazie (Meier)
UniBasel Contributors:Meier, Christoph R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Blackwell
ISSN:1750-2640
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:31
Deposited On:11 Oct 2012 15:18

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