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Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors

Cerdan, S. and Lotscher, H. R. and Kunnecke, B. and Seelig, J.. (1989) Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors. Magnetic Resonance in Medicine, 12 (2). pp. 151-163.

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Official URL: http://edoc.unibas.ch/dok/A5257479

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Abstract

A highly specific and powerful magnetic resonance imaging contrast agent has been prepared by coating magnetite (Fe3O4) particles with monoclonal antibodies directed against a tumor antigen. The preparation maintains both the immunoreactivity of the monoclonal antibody and the full relaxing capability of the magnetite particle. MRI image contrast by spin-echo methods can be easily induced in a concentration range of 1-10 nM of the antibody-coated magnetite particles.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:0740-3194
e-ISSN:1522-2594
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Nov 2017 13:39
Deposited On:22 Mar 2012 13:18

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