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Five challenges to bringing single-molecule force spectroscopy into living cells

Dufrene, Y. F. and Evans, E. and Engel, A. and Helenius, J. and Gaub, H. E. and Muller, D. J.. (2011) Five challenges to bringing single-molecule force spectroscopy into living cells. Nature Methods, Vol. 8, H. 2. pp. 123-127.

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Official URL: http://edoc.unibas.ch/dok/A6002461

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Abstract

In recent years, single-molecule force spectroscopy techniques have been used to study how inter- and intramolecular interactions control the assembly and functional state of biomolecular machinery in vitro. Here we discuss the problems and challenges that need to be addressed to bring these technologies into living cells and to learn how cellular machinery is controlled in vivo.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
UniBasel Contributors:Engel, Andreas H
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1548-7091
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:11 Oct 2012 15:31
Deposited On:11 Oct 2012 15:15

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