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Analysis of glycogen storage disease by in vivo 13C NMR : comparison of normal volunteers with a patient

Beckmann, N. and Seelig, J. and Wick, H.. (1990) Analysis of glycogen storage disease by in vivo 13C NMR : comparison of normal volunteers with a patient. Magnetic Resonance in Medicine, 16 (1). pp. 150-160.

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Official URL: http://edoc.unibas.ch/dok/A5257469

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Abstract

Broadband proton-decoupled natural abundance 13C spectra of the human calf, liver, and head were obtained from normal volunteers and a patient with glycogen type IIIA storage disease. Two concentric and coplanar surface coils of diameters 8.0 cm and 13.0 cm were used for 13C (at 16.0 MHz) and 1H (at 63.6 MHz), respectively. A WALTZ-8 sequence lead to homogeneous decoupling over a large volume. In addition to lipid resonances a variety of other metabolite resonances could be resolved. The glycogen concentration in the muscle and the liver of normal volunteers varied considerably depending on dietary preparation and physical exercise. The glycogen level in the liver and the calf of a patient with glycogen type IIIA storage disease was increased by a factor of 2-3 compared to normal, well-trained volunteers. Proton-decoupled 13C spectra of human head are reported for the first time. The spectra are dominated by lipid resonances but an additional resonance at 54.0 ppm is clearly visible. The proton-decoupled 13C head spectrum of a patient with glycogen type IIIA storage disease revealed additional resonances between 71.0 and 85.0 ppm.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:0740-3194
e-ISSN:1522-2594
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Nov 2017 13:22
Deposited On:22 Mar 2012 13:18

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