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Functional organization of the human anterior insular cortex

Mutschler, Isabella and Wieckhorst, Birgit and Kowalevski, Sandra and Derix, Johanna and Wentlandt, Johanna and Schulze-Bonhage, Andreas and Ball, Tonio. (2009) Functional organization of the human anterior insular cortex. Neuroscience Letters, 457 (2). pp. 66-70.

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Official URL: http://edoc.unibas.ch/dok/A5842009

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Abstract

The human insular cortex is involved in a wide range of functions including motor control, language, and homeostatic regulation. Little is known, however, how these functions are topographically organized in the insular cortex and how they are functionally related to the amygdala, which is anatomically connected to the insular cortex. We have investigated these questions by conducting an activation likelihood estimate (ALE) meta-analysis of previously published neuroimaging studies reporting insula effects. We find auditory and language tasks to preferentially activate an area in the dorsal part of the anterior insular cortex (AIC). Motor tasks involving both the upper and lower extremity reproducibly activated a posterior AIC region, adjacent to the sulcus centralis insulae (SCI). Significant co-activation with the probabilistically defined amygdala was located in the ventral AIC where also responses related to peripheral physiological changes were repeatedly reported. These findings show that the human AIC is a functionally differentiated brain region. The dorsal region of the AIC may be involved in auditory-motor integration, while the ventral part of the AIC may interface the amygdala with insular regions involved in the regulation of physiological changes related to emotional states. Thus, the present findings provide insights into the organization of human AIC and a methodological approach that may be further used to refine the emerging functional map of the insular cortex.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Mutschler, Isabella
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier/North-Holland
ISSN:0304-3940
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:27 Dec 2017 08:16
Deposited On:14 Sep 2012 07:16

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