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In vivo treatment with progestogens causes immunosuppression of carp Cyprinus carpio leucocytes by affecting nitric oxide production and arginase activity

Pietsch, Constanze and Neumann, Nadja and Preuer, Torsten and Kloas, Werner. (2011) In vivo treatment with progestogens causes immunosuppression of carp Cyprinus carpio leucocytes by affecting nitric oxide production and arginase activity. Journal of Fish Biology, 79 (1). pp. 53-69.

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Official URL: http://edoc.unibas.ch/dok/A6001567

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Abstract

In this study, carp Cyprinus carpio were injected with various steroid compounds, including syntheticand natural progestogens and the glucocorticoid cortisol, to investigate effects on leucocytesisolated from their kidneys. Injection of cortisol led to an increased spleeno-somatic index (IS) onday 21 post-injection (pi) and immunosuppressive effects measured as decreased nitric oxide (NO)production and increased arginase activity in isolated leucocytes on days 14 and 21 pi, respectively.Moreover, reduced NO production was also observed after injection of the synthetic progestogens,levonorgestrel (LEV) and medroxyprogesterone acetate. In addition, LEV influenced arginase activityin head kidney cells on day 14 and day 21 pi. This study is the first demonstration in fishes thatthe application of these steroid compounds in vivo affects NO production and arginase activity ofisolated leucocytes.
Faculties and Departments:05 Faculty of Science
05 Faculty of Science > Departement Umweltwissenschaften
05 Faculty of Science > Departement Umweltwissenschaften > Mensch Gesellschaft Umwelt MGU
UniBasel Contributors:Pietsch, Constanze
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley
ISSN:0022-1112
e-ISSN:1095-8649
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:13 Nov 2017 13:52
Deposited On:14 Sep 2012 07:15

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