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In vivo proton MR spectroscopy of human gliomas : definition of metabolic coordinates for multi-dimensional classification

Hagberg, G. and Burlina, A. P. and Mader, I. and Roser, W. and Radue, E. W. and Seelig, J.. (1995) In vivo proton MR spectroscopy of human gliomas : definition of metabolic coordinates for multi-dimensional classification. Magnetic Resonance in Medicine, 34 (2). pp. 242-252.

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Official URL: http://edoc.unibas.ch/dok/A5257442

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Abstract

Several multi-dimensional statistical evaluation methods were applied to single-voxel proton MR spectra of glial brain tumors and of healthy volunteers. Metabolic coordinates with histological relevance for future diagnosis were found by which spectra from controls, low-grade tumors, and high-grade tumors were completely separated. Significant differences between low-grade and high-grade glioma patients and controls were found for several metabolic ratios by variance analysis. Cluster analysis both with and without principal component analysis was applied. The outcome of these two approaches depended mainly on the lipid-to-creatine ratio. Two other approaches, discriminant factor analysis and the orthonormal discriminant vector method were then used to find discriminatory metabolic coordinates. It turned out that a linear combination of all evaluable metabolic ratios made it possible to separate the three groups completely. On the basis of these results, a classification method that uses the entire proton MRS spectrum is proposed.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:0740-3194
e-ISSN:1522-2594
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Nov 2017 13:20
Deposited On:22 Mar 2012 13:18

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