Proton MRS of gadolinium-enhancing MS plaques and metabolic changes in normal-appearing white matter

Roser, W. and Hagberg, G. and Mader, I. and Brunnschweiler, H. and Radue, E. W. and Seelig, J. and Kappos, L.. (1995) Proton MRS of gadolinium-enhancing MS plaques and metabolic changes in normal-appearing white matter. Magnetic Resonance in Medicine, 33 (6). pp. 811-817.

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Official URL: http://edoc.unibas.ch/dok/A5257443

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Localized short echo time (TE = 20 ms), stimulated echo acquisition mode, and double spin echo (TE = 135 ms) proton spectroscopy were performed in clearly defined, acute Gadolinium (Gd)-enhancing multiple sclerosis (MS) plaques of 22 patients with clinically definite MS. The resonances of N-acetylated metabolites (NA), creatine/phosphocreatine (Cr), choline-containing compounds (Cho), glycine/myo-inositol (Ino), and lactate were evaluated. The ratios of NA/Cr and NA/Cho were significantly decreased, Cho/Cr increased, and Ino/Cr remained unchanged. No marker peaks or elevated lactate levels were found. The measured metabolic changes were practically independent of the relative plaque size within the volume of interest (8 ml). Thus, the spectral changes measured with 1H MRS in acute Gd-enhancing MS plaques originate not only from the lesion as depicted by MRI, but also from the surrounding normal-appearing white matter.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Nov 2017 13:19
Deposited On:22 Mar 2012 13:18

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