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Spray freeze drying in a fluidized bed at normal and low pressure

Leuenberger, H. and Plitzko, M. and Puchkov, M.. (2006) Spray freeze drying in a fluidized bed at normal and low pressure. Drying technology, Vol. 24, H. 6. pp. 711-719.

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Official URL: http://edoc.unibas.ch/dok/A6001387

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Abstract

The aim of this study is to develop the spray freeze drying process and its hardware and to investigate its capabilities to dry thermosensible substances such as pharma-proteins at normal and low pressures. As the result, the spray freeze fluidized-bed dryer was constructed. During the study, the drying kinetic comparison between classical and spray freeze-drying technologies was done. Spray freeze drying has shown short process times and allows advanced control, product particle shape and size uniformity, and high solubility. This shows that the fluidized-bed freeze-drying process could be an alternative for classical freeze-drying processes. Identified problems are the low yield of the primary drying phase and the strong electrostatic effects during the secondary drying step. However, the innovative process has shown an excellent capability to dry and stabilize the thermosensitive substances, such as pharma-proteins.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Technologie (Huwyler)
UniBasel Contributors:Puchkov, Maxim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Taylor & Francis
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:21
Deposited On:14 Sep 2012 07:13

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