Frontocortical N-acetylaspartate reduction associated with long-term iv heroin use

Haselhorst, R. and Dursteler-MacFarland, K. M. and Scheffler, K. and Ladewig, D. and Muller-Spahn, F. and Stohler, R. and Seelig, J. and Seifritz, E.. (2002) Frontocortical N-acetylaspartate reduction associated with long-term iv heroin use. Neurology, Vol. 58, H. 2. pp. 305-307.

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Official URL: http://edoc.unibas.ch/dok/A5257396

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To examine possible metabolic frontal lobe alterations in i.v. heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by (1)H-MRS. Compared with controls, NAA levels in patients were reduced by 7% in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:19
Deposited On:22 Mar 2012 13:18

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