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Protein-based hybrid catalysts-design and evolution

Koehler, Valentin and Wilson, Yvonne M. and Lo, Cheikh and Sardo, Alessia and Ward, Thomas R.. (2010) Protein-based hybrid catalysts-design and evolution. Current Opinion in Biotechnology, 21 (6). pp. 744-752.

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Official URL: http://edoc.unibas.ch/dok/A5841556

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Abstract

Artificial metalloenzymes result from the introduction of a catalytically competent non-native metal cofactor within a protein environment. In the present contribution, we summarize the recent achievements in the design and the optimization of such protein-based hybrid catalysts, with an emphasis on enantioselective transformations. The second part outlines the milestones required to achieve en masse prodn., screening and directed evolution of artificial metalloenzymes. In the spirit of Darwinian evolution, this will allow the full potential of such protein-based hybrid catalysts to be fully unraveled, thus complementing both homogeneous and enzymic catalysis. [on SciFinder(R)]
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0958-1669
e-ISSN:1879-0429
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:24 Apr 2017 10:13
Deposited On:14 Sep 2012 07:00

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