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Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption

Navarini, Alexander A. and Stoeckle, Marcel and Navarini, Susanne and Mossdorf, Erik and Jullu, Boniphace S. and Mchomvu, Rehema and Mbata, Marco and Kibatala, Patience and Tanner, Marcel and Hatz, Christoph and Schmid-Grendelmeier, Peter. (2010) Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption. International journal of dermatology, 49 (1). pp. 83-86.

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Official URL: http://edoc.unibas.ch/dok/A5842814

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Abstract

Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P > 0.0058) and clinical scores (P > 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Clinical Immunology (Daubenberger)
UniBasel Contributors:Tanner, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
ISSN:0011-9059
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Feb 2018 12:29
Deposited On:14 Sep 2012 06:50

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