African 1, an epidemiologically important clonal complex of Mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad

Müller, B. and Hilty, M. and Berg, S. and Garcia-Pelayo M. C., and Dale, J. and Boschiroli, M. L. and Cadmus, S. and Ngandolo, B. N. and Godreuil, S. and Diguimbaye-Djaibe C., and Kazwala, R. and Bonfoh, B. and Njanpop-Lafourcade B. M., and Sahraoui, N. and Guetarni, D. and Aseffa, A. and Mekonnen, M. H. and Razanamparany, V. R. and Ramarokoto, H. and Djonne, B. and Oloya, J. and Machado, A. and Mucavele, C. and Skjerve, E. and Portaels, F. and Rigouts, L. and Michel, A. and Muller, A. and Kallenius, G. and van Helden P. D., and Hewinson, R. G. and Zinsstag, J. and Gordon, S. V. and Smith, N. H.. (2009) African 1, an epidemiologically important clonal complex of Mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad. Journal of bacteriology : a publication of the American Society for Microbiology, Vol. 191, H. 6. pp. 1951-1960.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5843132

Downloads: Statistics Overview


We have identified a clonal complex of Mycobacterium bovis present at high frequency in cattle in population samples from several sub-Saharan west-central African countries. This closely related group of bacteria is defined by a specific chromosomal deletion (RDAf1) and can be identified by the absence of spacer 30 in the standard spoligotype typing scheme. We have named this group of strains the African 1 (Af1) clonal complex and have defined the spoligotype signature of this clonal complex as being the same as the M. bovis BCG vaccine strain but with the deletion of spacer 30. Strains of the Af1 clonal complex were found at high frequency in population samples of M. bovis from cattle in Mali, Cameroon, Nigeria, and Chad, and using a combination of variable-number tandem repeat typing and spoligotyping, we show that the population of M. bovis in each of these countries is distinct, suggesting that the recent mixing of strains between countries is not common in this area of Africa. Strains with the Af1-specific deletion (RDAf1) were not identified in M. bovis isolates from Algeria, Burundi, Ethiopia, Madagascar, Mozambique, South Africa, Tanzania, and Uganda. Furthermore, the spoligotype signature of the Af1 clonal complex has not been identified in population samples of bovine tuberculosis from Europe, Iran, and South America. These observations suggest that the Af1 clonal complex is geographically localized, albeit to several African countries, and we suggest that the dominance of the clonal complex in this region is the result of an original introduction into cows naive to bovine tuberculosis
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Human and Animal Health > One Health (Zinsstag)
UniBasel Contributors:Zinsstag, Jakob Z
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Microbiology
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:14 Sep 2012 07:18
Deposited On:14 Sep 2012 06:46

Repository Staff Only: item control page