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Caught in action : mechanistic insights into antibody-mediated inhibition of Plasmodium merozoite invasion

Treeck, M. and Tamborrini, M. and Daubenberger, C. A. and Gilberger, T. W. and Voss, Till S.. (2009) Caught in action : mechanistic insights into antibody-mediated inhibition of Plasmodium merozoite invasion. Trends in parasitology, Vol. 25, H. 11. pp. 494-497.

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Official URL: http://edoc.unibas.ch/dok/A5843161

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Abstract

Apical membrane antigen 1 (AMA1) plays an essential role in host cell invasion by apicomplexan parasites. A recent study by Collins et al. investigated the mode of action of an anti-AMA1 invasion-inhibitory antibody. They demonstrated the interference of this antibody with invasion complex formation, which was dependent in turn on a single conserved tyrosine residue in AMA1. Their findings reveal important new insights into parasite biology and are highly relevant for rational vaccine design
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Gene Regulation (Voss)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Voss, Till S and Tamborrini, Marco
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1471-4922
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Nov 2018 13:36
Deposited On:14 Sep 2012 06:46

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