Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda

Mueller, Y. and Mbulamberi, D. B. and Odermatt, P. and Hoffmann, A. and Loutan, L. and Chappuis, F.. (2009) Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda. Tropical medicine and international health : TM & IH : a European journal, 14 (8). pp. 910-917.

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Official URL: http://edoc.unibas.ch/dok/A5843311

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OBJECTIVE: To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda. METHODS: Retrospective analysis of VL patients' clinical data collected for project monitoring by Medecins Sans Frontieres in Amudat, eastern Uganda. RESULTS: Between 2000 and 2005, of 3483 clinically suspect patients, 53% were confirmed with primary VL. Sixty-two per cent were children 0.20). The main risk factors for in-hospital death identified by a multivariate analysis were age 15 years, concomitant tuberculosis or hepatopathy, and drug-related adverse events. The case-fatality rate among patients <45 years of age was strikingly high (29.0%). CONCLUSION: Subgroups of VL patients at higher risk of death during treatment with drugs currently available in Uganda were identified. Less toxic drugs should be evaluated and used in these patients
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Health Impact Assessment (Utzinger)
UniBasel Contributors:Odermatt, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Nov 2017 09:56
Deposited On:14 Sep 2012 06:43

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