Attractive-mode imaging of biological materials with dynamic force microscopy

Anselmetti, D. and Luthi, R. and Meyer, E. and Richmond, T. and Dreier, M. and Frommer, J. E. and Guntherodt, H. J.. (1994) Attractive-mode imaging of biological materials with dynamic force microscopy. Nanotechnology, Vol. 5, H. 2. pp. 87-94.

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Official URL: http://edoc.unibas.ch/dok/A5839486

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We have applied the non-contact dynamic force microscopy method to investigate soft biological materials such as hexagonally-packed intermediate layers, DNA, and tobacco mosaic virus under ambient conditions. This method, where a stiff cantilever is oscillated close to its resonance frequency with an amplitude of 0.3-1.5 nm above the sample, allows highly reliable investigation of soft organic matter with minimized normal and lateral forces between tip and sample. The vertical and lateral resolution are determined to be > 1 angstrom and 1-2 nm, respectively, comparing favorably to established results from repulsive-mode scanning force microscopy experiments on absorbate covered surfaces in liquids. The interaction forces are found to be attractive, dominated by damping mechanisms and attractive force gradients of capillary and van der Waals interactions.
Faculties and Departments:05 Faculty of Science > Departement Physik > Physik > Nanomechanik (Meyer)
UniBasel Contributors:Meyer, Ernst
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:IOP Publ.
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:18
Deposited On:14 Sep 2012 06:43

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