Biological materials studied with dynamic force microscopy

Anselmetti, D. and Dreier, M. and Luthi, R. and Richmond, T. and Meyer, E. and Frommer, J. and Guntherodt, H. J.. (1994) Biological materials studied with dynamic force microscopy. Journal of vacuum science & technology. B, Microelectronics and nanometer structures processing, measurement, and phenomena, Vol. 12, H. 3. pp. 1500-1503.

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Official URL: http://edoc.unibas.ch/dok/A5839489

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Biological materials such as hexagonal packed intermediate (HPI) layers, DNA, tobacco mosaic virus and collagen deposited on various substrates with noncontact dynamic force microscopy under ambient conditions were investigated. This method is highly suited for the investigation of soft organic matter where a minimized interaction between tip and sample is needed for nondestructive and reliable operation. Hence, additional anchoring of the biological specimens was no longer found to be crucial. The vertical and lateral resolution limits of this gentle method were determined to be >0.1 nm and 1-2 nm, respectively, allowing very stable and high resolution results on all investigated systems. By taking approach curves and monitoring the dynamic properties of the cantilever (resonance frequency and Q value) during the experiment, the interaction mechanism between tip and sample was found to-be dominated by attractive van der Waals interaction and capillary forces. Furthermore, initial results from a HPI layer imaged with noncontact dynamic force microscopy in a water environment are presented.
Faculties and Departments:05 Faculty of Science > Departement Physik > Physik > Nanomechanik (Meyer)
UniBasel Contributors:Meyer, Ernst
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Vacuum Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:18
Deposited On:14 Sep 2012 06:43

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