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The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

Roy, R. and Adamczewski, J. P. and Seroz, T. and Vermeulen, W. and Tassan, J. P. and Schaeffer, L. and Nigg, E. A. and Hoeijmakers, J. H. and Egly, J. M.. (1994) The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell, Vol. 79, H. 6. pp. 1093-1101.

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Official URL: http://edoc.unibas.ch/dok/A5249460

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Abstract

A protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Nigg)
UniBasel Contributors:Nigg, Erich A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0092-8674
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:19
Deposited On:22 Mar 2012 13:17

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