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Brain development in the yellow fever mosquito Aedes aegypti : a comparative immunocytochemical analysis using cross-reacting antibodies from Drosophila melanogaster

Mysore, Keshava and Flister, Susanne and Müller, Pie and Rodrigues, Veronica and Reichert, Heinrich. (2011) Brain development in the yellow fever mosquito Aedes aegypti : a comparative immunocytochemical analysis using cross-reacting antibodies from Drosophila melanogaster. Development genes and evolution, Vol. 221. pp. 281-296.

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Official URL: http://edoc.unibas.ch/dok/A5848252

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Abstract

Considerable effort has been directed towards understanding the organization and function of peripheral and central nervous system of disease vector mosquitoes such as Aedes aegypti. To date, all of these investigations have been carried out on adults but none of the studies addressed the development of the nervous system during the larval and pupal stages in mosquitoes. Here, we first screen a set of 30 antibodies, which have been used to study brain development in Drosophila, and identify 13 of them cross-reacting and labeling epitopes in the developing brain of Aedes. We then use the identified antibodies in immunolabeling studies to characterize general neuroanatomical features of the developing brain and compare them with the well-studied model system, Drosophila melanogaster, in larval, pupal, and adult stages. Furthermore, we use immunolabeling to document the development of specific components of the Aedes brain, namely the optic lobes, the subesophageal neuropil, and serotonergic system of the subesophageal neuropil in more detail. Our study reveals prominent differences in the developing brain in the larval stage as compared to the pupal (and adult) stage of Aedes. The results also uncover interesting similarities and marked differences in brain development of Aedes as compared to Drosophila. Taken together, this investigation forms the basis for future cellular and molecular investigations of brain development in this important disease vector.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Vector Control Centre (Müller)
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Zoology (Reichert)
UniBasel Contributors:Müller, Pie and Reichert, Heinrich and Flister, Susanne and Mysore Ramashesha, Keshava Subramanya
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0949-944X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2012 16:12
Deposited On:14 Sep 2012 06:40

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