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Target of Rapamycin (TOR) in nutrient signaling and growth control

Loewith, R. and Hall, M. N.. (2011) Target of Rapamycin (TOR) in nutrient signaling and growth control. Genetics, 189 (4). pp. 1177-1201.

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Official URL: http://edoc.unibas.ch/dok/A5848955

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Abstract

TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Genetics Society of America
ISSN:0016-6731
e-ISSN:1943-2631
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:20 Nov 2017 09:49
Deposited On:14 Sep 2012 06:40

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