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mTOR signaling in disease

Dazert, E. and Hall, M. N.. (2011) mTOR signaling in disease. Current Opinion in Cell Biology, 23 (6). pp. 744-755.

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Official URL: http://edoc.unibas.ch/dok/A5848537

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Abstract

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0955-0674
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Nov 2017 10:17
Deposited On:14 Sep 2012 06:40

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