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Salmonella-Induced Mucosal Lectin RegIIIbeta Kills Competing Gut Microbiota

Stelter, C. and Kappeli, R. and Konig, C. and Krah, A. and Hardt, W. -D. and Stecher, B. and Bumann, D.. (2011) Salmonella-Induced Mucosal Lectin RegIIIbeta Kills Competing Gut Microbiota. PLoS ONE, 6 (6). e20749.

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Official URL: http://edoc.unibas.ch/dok/A5844165

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Abstract

Intestinal inflammation induces alterations of the gut microbiota and promotes overgrowth of the enteric pathogen Salmonella enterica by largely unknown mechanisms. Here, we identified a host factor involved in this process. Specifically, the C-type lectin RegIIIbeta is strongly upregulated during mucosal infection and released into the gut lumen. In vitro, RegIIIbeta kills diverse commensal gut bacteria but not Salmonella enterica subspecies I serovar Typhimurium (S. Typhimurium). Protection of the pathogen was attributable to its specific cell envelope structure. Co-infection experiments with an avirulent S. Typhimurium mutant and a RegIIIbeta-sensitive commensal E. coli strain demonstrated that feeding of RegIIIbeta was sufficient for suppressing commensals in the absence of all other changes inflicted by mucosal disease. These data suggest that RegIIIbeta production by the host can promote S. Typhimurium infection by eliminating inhibitory gut microbiota.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:31 Aug 2018 06:33
Deposited On:14 Sep 2012 06:38

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