Pentagone: patrolling BMP morphogen signaling

Vuilleumier, Robin and Affolter, Markus and Pyrowolakis, George. (2011) Pentagone: patrolling BMP morphogen signaling. Fly, Vol. 5, H. 3. pp. 210-214.

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Official URL: http://edoc.unibas.ch/dok/A5844190

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Orchestration of spatial organization by signaling gradients - morphogen gradients - is a fundamental principle in animal development. Despite their importance in tissue patterning and growth, the exact mechanisms underlying the establishment and maintenance of morphogen gradients are poorly understood. Our recent work on BMP (bone morphogenetic protein) morphogen signaling during wing development identified a novel protein, Pentagone (Pent), as a critical regulator of morphogen activity. In the following, we discuss the properties of Pent and its role as a feed-back loop in morphogen gradient formation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Landes Bioscience
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Sep 2015 14:31
Deposited On:14 Sep 2012 06:38

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