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Semaphorin-PlexinD1 Signaling Limits Angiogenic potential via the VEGF Decoy Receptor sFlt1

Zygmunt, T. and Blondelle, J. and Singh, M. K. and McCrone Flaherty, K. and Casey Means, P. and Herwig, L. and Krudewig, A. and Belting, H. -G. and Affolter, M. and Epstein, J. A. and Torres-Vazquez, J.. (2011) Semaphorin-PlexinD1 Signaling Limits Angiogenic potential via the VEGF Decoy Receptor sFlt1. Developmental cell, Vol. 21, H. 2. pp. 301-314.

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Official URL: http://edoc.unibas.ch/dok/A5844187

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Abstract

Sprouting angiogenesis expands the embryonic vasculature enabling survival and homeostasis. Yet how the angiogenic capacity to form sprouts is allocated among endothelial cells (ECs) to guarantee the reproducible anatomy of stereotypical vascular beds remains unclear. Here we show that Sema-PlxnD1 signaling, previously implicated in sprout guidance, represses angiogenic potential to ensure the proper abundance and stereotypical distribution of the trunk`s segmental arteries (SeAs). We find that Sema-PlxnD1 signaling exerts this effect by antagonizing the proangiogenic activity of vascular endothelial growth factor (VEGF). Specifically, Sema-PlxnD1 signaling ensures the proper endothelial abundance of soluble flt1 (sflt1), an alternatively spliced form of the VEGF receptor Flt1 encoding a potent secreted decoy. Hence, Sema-PlxnD1 signaling regulates distinct but related aspects of angiogenesis: the spatial allocation of angiogenic capacity within a primary vessel and sprout guidance.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:1534-5807
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:17
Deposited On:14 Sep 2012 06:38

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