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Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels

Schulz, Joachim G. and Ceulemans, Helga and Caussinus, Emmanuel and Baietti, Maria F. and Affolter, Markus and Hassan, Bassem A. and David, Guido. (2011) Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels. EMBO reports, Vol. 12, H. 10. pp. 1039-1046.

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Official URL: http://edoc.unibas.ch/dok/A5844137

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Abstract

Here we identify a new role for Syndecan (Sdc), the only transmembrane heparan sulphate proteoglycan in Drosophila, in tracheal development. Sdc is required cell autonomously for efficient directed migration and fusion of dorsal branch cells, but not for dorsal branch formation per se. The cytoplasmic domain of Sdc is dispensable, indicating that Sdc does not transduce a signal by itself. Although the branch-specific phenotype of sdc mutants resembles those seen in the absence of Slit/Robo2 signalling, genetic interaction experiments indicate that Sdc also helps to suppress Slit/Robo2 signalling. We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1469-221X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:06
Deposited On:14 Sep 2012 06:38

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