Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder

Schulze, T. G. and Müller, D. J. and Krauss, H. and Scherk, H. and Ohlraun, S. and Syagailo, Y. V. and Windemuth, C. and Neidt, H. and Grässle, M. and Papassotiropoulos, A. and Heun, R. and Nöthen, M. M. and Maier, W. and Lesch, K. P. and Rietschel, M.. (2000) Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. American journal of medical genetics, Vol. 96, no. 6. pp. 801-803.

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Official URL: http://edoc.unibas.ch/dok/A5257206

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Various polymorphisms of the X-chromosomal monoamine oxidase A (MAO-A) gene were investigated for association with affective disorders. However, none of the studied variants could consistently be associated with either major depressive or bipolar affective disorder. Recently, a positive association between panic disorder and a novel functional repeat polymorphism in the MAO-A gene promoter, with the longer alleles being more active, was reported. Since monoaminergic neurotransmission is supposed to play an important role in affective disorders, we investigated a potential association of this polymorphism with major depressive illness in a sample of 146 unrelated patients of German descent and a control group of 101 individuals with a negative life history for affective disorders. Similarly to the recent findings in panic disorder, we observed a significantly increased frequency of genotypes containing only long alleles in female patients with recurrent major depression in comparison with age- and sex-matched controls. Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Molecular Neuroscience (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:19
Deposited On:22 Mar 2012 13:17

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