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The maturation of vessels : a limitation to forced neovascularization?

Banfi, Andrea and Fueglistaler, Philipp and Gianni-Barrera, Roberto. (2007) The maturation of vessels : a limitation to forced neovascularization? In: Therapeutic neovascularization–quo vadis?. Dordrecht, pp. 139-158.

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Official URL: http://edoc.unibas.ch/dok/A5839829

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Abstract

Therapeutic angiogenesis is the induction of new blood vessels by the delivery of appropriate growth factors and is an attractive approach to the treatment of different ischemic conditions. The experience with initial clinical trials in the past decade has shown that this may be more complex than anticipated and highlights the need to incorporate current advancements in our understanding of the regulation of vessel growth in the design of novel strategies. The generation of new capillaries from neighboring microvasculature by angiogenesis can be represented as a two-step process: 1) tube formation, in which endothelial cells respond to gradients of angiogenic factors, proliferate and migrate towards areas where increased blood flow is needed, and 2) vascular maturation, in which pericytes are recruited to proliferating endothelium and induce quiescence and stabilization of the new capillaries through cell-cell contact and paracrine factors. The formation of a new vascular network with normal morphology and physiological function requires a proper balance between these two processes. Here we will review the current understanding of how the growth of normal or pathological blood vessels is determined by growth factor gradients in the microenvironment and what lessons can be learned to design more physiological strategies to achieve therapeutic angiogenesis for the treatment of ischemia. In particular, we will discuss the possibility to exploit vascular maturation as a target distinct from vessel induction, but capable of modulating the effects of angiogenic factors, and its implications for increasing safety and efficacy of therapeutic angiogenesis strategies.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cell and Gene Therapy (Banfi)
03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Innere Organe > Gefässchirurgie (Stierli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Innere Organe > Gefässchirurgie (Stierli)
UniBasel Contributors:Banfi, Andrea
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Bibsysno:Link to catalogue
Publisher:Springer
ISBN:978-1-4020-5955-1 ; 978-1-4020-5954-4
Note:Publication type according to Uni Basel Research Database: Book item
Identification Number:
Last Modified:13 Apr 2018 06:17
Deposited On:08 Jun 2012 06:50

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