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Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa : a clinical trial of immunogenicity in lower airways of human volunteers

Bumann, D. and Behre, C. and Behre, K. and Herz, S. and Gewecke, B. and Gessner, J. E. and von Specht, B. U. and Baumann, U.. (2009) Systemic, nasal and oral live vaccines against Pseudomonas aeruginosa : a clinical trial of immunogenicity in lower airways of human volunteers. Vaccine, 28 (3). pp. 707-713.

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Official URL: http://edoc.unibas.ch/dok/A5259795

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Abstract

Vaccination against Pseudomonas aeruginosa is a desirable, yet challenging strategy for prevention of airway infection in patients with cystic fibrosis. We compared the formation of antibodies in lower airways induced by systemic and mucosal vaccination strategies. We immunised 48 volunteers in six vaccination groups with either a systemic, a nasal, or four newly constructed oral live vaccines based on attenuated live Salmonella (strains CVD908 and Ty21a), followed by a systemic booster vaccination. All vaccines were based on a recombinant fusion protein of the highly conserved P. aeruginosa outer membrane proteins OprF and OprI as antigen. While systemic and mucosal vaccines induced a comparable rise of serum antibody titers, a significant rise of IgA and IgG antibodies in the lower airways was noted only after nasal and oral vaccinations. We conclude that nasal and oral OprF-OprI vaccines are promising candidates for development of antipseudomonal immunisation through inducing a specific antibody response in the lung.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Bumann)
UniBasel Contributors:Bumann, Dirk
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0264-410X
e-ISSN:1873-2518
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Nov 2017 07:55
Deposited On:08 Jun 2012 06:49

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