Zona Pellucida Domain Proteins Remodel the Apical Compartment for Localized Cell Shape Changes

Fernandes, I. and Chanut-Delande, H. and Ferrer, P. and Latapie, Y. and Waltzer, L. and Affolter, M. and Payre, F. and Plaza, S.. (2010) Zona Pellucida Domain Proteins Remodel the Apical Compartment for Localized Cell Shape Changes. Developmental cell, Vol. 18. pp. 64-76.

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Official URL: http://edoc.unibas.ch/dok/A5842474

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The zona pellucida domain (ZPD) defines a conserved family of membrane-anchored matrix proteins that are, as yet, poorly characterized with respect to their functions during development. Using genetic approaches in flies, we show here that a set of eight ZPD proteins is required for the localized reorganization of embryonic epidermal cells during morphogenesis. Despite varying degrees ofsequence conservation, these ZPD proteins exert specific and nonredundant functions in the remodeling of epidermal cell shape. Each one accumulates ina restricted subregion of the apical compartment, where it organizes local interactions between the membrane and the extracellular matrix. In addition,ZPD proteins are required to sculpture the actinrich cell extensions and maintain appropriate organization of the apical compartment. These results on ZPD proteins therefore reveal a functional subcompartmentalization of the apical membrane and its role in the polarized control of epithelial cell shape during development.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:56
Deposited On:08 Jun 2012 06:49

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