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A conserved activation element in BMP signaling during Drosophila development

Weiss, A. and Charbonnier, E. and Ellertsdottir, E. and Tsirigos, A. and Wolf, C. and Schuh, R. and Pyrowolakis, G. and Affolter, M.. (2010) A conserved activation element in BMP signaling during Drosophila development. Nature structural & molecular biology, Vol. 17, no. 1. pp. 69-76.

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Official URL: http://edoc.unibas.ch/dok/A5258888

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Abstract

The transforming growth factor β (TGF-β) family member Decapentaplegic (Dpp) is a key regulator of patterning and growth in Drosophila development. Previous studies have identified a short DNA motif called the silencer element (SE), which recruits a trimeric Smad complex and the repressor Schnurri to downregulate target enhancers upon Dpp signaling. We have now isolated the minimal enhancer of the dad gene and discovered a short motif we termed the activating element (AE). The AE is similar to the SE and recruits the Smad proteins via a conserved mechanism. However, the AE and SE differ at important nucleotide positions. As a consequence, the AE does not recruit Schnurri but rather integrates repressive input by the default repressor Brinker and activating input by the Smad signal transducers Mothers against Dpp (Mad) and Medea via competitive DNA binding. The AE allows the identification of hitherto unknown direct Dpp targets and is functionally conserved in vertebrates.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publ. Group
ISSN:1545-9993
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Jan 2016 07:45
Deposited On:08 Jun 2012 06:49

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