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Fast quantitative single-molecule detection at ultralow concentrations

Haas, Philippe and Then, Patrick and Wild, Andreas and Grange, Wilfried and Zorman, Sylvain and Hegner, Martin and Calame, Michel and Aebi, Ueli and Flammer, Josef and Hecht, Bert. (2010) Fast quantitative single-molecule detection at ultralow concentrations. Analytical chemistry, Vol. 82. pp. 6299-6302.

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Official URL: http://edoc.unibas.ch/dok/A5847986

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Abstract

The applicability of single-molecule fluorescence assays in liquids is limited by diffusion to concentrations in the low picomolar range. Here, we demonstrate quantitative single-molecule detection at attomolar concentrations within 1 min by excitation and detection of fluorescence through a single-mode optical fiber in presence of turbulent flow. The combination of high detectability and short measurement times promises applications in ultrasensitive assays, sensors, and point-of-care medical diagnostics.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Aebi)
UniBasel Contributors:Aebi, Ueli and Flammer, Josef
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:0003-2700
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Dec 2012 13:03
Deposited On:08 Jun 2012 06:49

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