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Genetic association of acyl-coenzyme A : cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease

Wollmer, M. A. and Streffer, J. R. and Tsolaki, M. and Grimaldi, L. M. E. and Lütjohann, D. and Thal, D. and von Bergmann, K. and Nitsch, R. M. and Hock, C. and Papassotiropoulos, A.. (2003) Genetic association of acyl-coenzyme A : cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease. Molecular psychiatry, Vol. 8, H. 6. pp. 635-638.

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Official URL: http://edoc.unibas.ch/dok/A5257181

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Abstract

A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations (P=0.0001, odds ratio: 0.6, 95% confidence interval 0.4-0.8).
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1359-4184
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 06:39
Deposited On:22 Mar 2012 13:17

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