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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A

Meraldi, P. and Lukas, J. and Fry, A. M. and Bartek, J. and Nigg, E. A.. (1999) Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nature Cell Biology, Vol. 1, H. 2. pp. 88-93.

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Official URL: http://edoc.unibas.ch/dok/A5249424

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Abstract

Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division. In a manner highly reminiscent of DNA replication, the centrosome must be duplicated once, and only once, in each cell cycle. How centrosome duplication is regulated and coordinated with other cell-cycle functions remains poorly understood. Here, we have established a centrosome duplication assay using mammalian somatic cells. We show that centrosome duplication requires the activation of E2F transcription factors and Cdk2-cyclin A activity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Nigg)
UniBasel Contributors:Nigg, Erich A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:MacMillan
ISSN:1465-7392
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:19
Deposited On:22 Mar 2012 13:17

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