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Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide

Oberli, M. A. and Tamborrini, M. and Tsai, Y. H. and Werz, D. B. and Horlacher, T. and Adibekian, A. and Gauss, D. and Möller, H. M. and Pluschke, G. and Seeberger, P. H.. (2010) Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide. Journal of the American Chemical Society, Vol. 132, H. 30. pp. 10239-10241.

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Official URL: http://edoc.unibas.ch/dok/A5842953

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Abstract

The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation transfer difference NMR spectroscopy was used to dissect the antibody-binding surface of a carbohydrate antigen, revealing crucial binding elements with atomic-level detail. This analysis takes the first step toward uncovering the rules for structure-based design of carbohydrate antigens
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Molecular Diagnostics (Felger)
UniBasel Contributors:Tamborrini, Marco and Prein, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Chemical Society
ISSN:0002-7863
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:56
Deposited On:08 Jun 2012 06:47

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