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Adverse drug event rates in six community hospitals and the potential impact of computerized physician order entry for prevention

Hug, Balthasar L. and Witkowski, Daniel J. and Sox, Colin M. and Keohane, Carol A. and Seger, Diane L. and Yoon, Catherine and Matheny, Michael E. and Bates, David W.. (2010) Adverse drug event rates in six community hospitals and the potential impact of computerized physician order entry for prevention. Journal of general internal medicine, 25 (1). pp. 31-38.

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Official URL: http://edoc.unibas.ch/dok/A5841413

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Abstract

Medications represent a major cause of harm and are costly for hospitalized patients, but more is known about these issues in large academic hospitals than in smaller hospitals.; To assess the incidence of adverse drug events (ADEs) in six community hospitals.; Multicenter, retrospective cohort study.; Six Massachusetts community hospitals with 100 to 300 beds.; From 109,641 adult patients hospitalized from January 2005 through August 2006, a random sample of 1,200 patients was drawn, 200 per site.; ADEs and preventable ADEs.; Presence of an ADE was evaluated using an adaptation of a trigger instrument developed by the Institute for Health Care Improvement. Independent reviewers classified events by preventability, severity, and potential for preventability by computerized physician order entry (CPOE).; A total of 180 ADEs occurred in 141 patients (rate, 15.0/100 admissions). Overall, 75% were preventable. ADEs were rated as serious in 49.4% and life threatening in 11.7%. Patients with ADEs were older (mean age, 74.6 years, p > 0.001), more often female (60.3%, p = 0.61), and more often Caucasian (96.5%, p > 0.001) than patients without ADEs. Of the preventable ADEs, 81.5% were judged potentially preventable by CPOE.; The incidence of ADEs in these community hospital admissions was high, and most ADEs were preventable, mostly through CPOE. These data suggest that CPOE may be beneficial in this setting.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Stationäre innere Medizin (Schifferli)
UniBasel Contributors:Hug, Balthasar L.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell Science
ISSN:0884-8734
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Mar 2019 15:21
Deposited On:08 Jun 2012 06:46

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